Synthesis and Characterization of Isomeric Vinyl-1,2,3-triazole Materials by Azide-Alkyne Click Chemistry

نویسندگان

  • Hunaid Nulwala
  • Kenichi Takizawa
  • Anika Odukale
  • Anzar Khan
  • Raymond J. Thibault
  • Benjamin R. Taft
  • Bruce H. Lipshutz
  • Craig J. Hawker
چکیده

The synthesis of isomeric, functionalized 4-vinyl-1,2,3-triazole and 5-vinyl-1,2,3-triazole monomers is demonstrated using heterogeneous copper (copper-in-charcoal)-catalyzed azide-alkyne cycloaddition (CuAAC) or homogeneous ruthenium (Ru)-catalyzed azide-alkyne cycloadditions (RuAAC) “click” protocols. These reactions are regiospecific, exclusively forming 1,4and 1,5-disubstituted triazoles as determined by H NMR, C NMR, and X-ray crystallography analysis. Polymerizations were performed using living free radical procedures to yield materials with divergent properties. In the case of the 1,5-triazole materials, glass transition temperature were significantly higher that for the 1,4-derivatives while solubility was decreased.

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تاریخ انتشار 2009